was born in Paris to an Ashkenazi Polish Jewish father, Albert Zylberstein, and a Catholic mother, her father is a physicist. Previously, Zylberstein considered herself Jewish, but now she is more attracted by Buddhism. She has practiced classical dance since her childhood. After a ferry A3, she began university and studies English, but it's the life of artist who draws her. She incorporate the same class of free of the Cours Florent of Francis Huster.
Appeared for the first time on screen in 1989 in Baptême, on the filming of Van Gogh directed by Maurice Pialat, she will be out by obtaining the Price Michel Simon in 1992, and the first of his three appointments to the César Award for Most Promising Actress. Student mischievous in Beau fixe, Zylberstein, winner of the Prix Romy Schneider
in 1993, inspires young directors like Pascale Bailly, Diane Bertrand and especially Martine Dugowson, who she becomes actress-fetish. The filmmaker offered to her the lead role, alongside Romane Bohringer
, of Mina Tannenbaum, story of a friendship that gets a fair amount of success public in 1994. Actress in passionate displays soon a predilection for the old films, Farinelli of Mr N. through Jefferson in Paris. The discovery that she was in the arms of the painter of Auvers-sur-Oise, embodies Suzanne Valadon in Lautrec, and then the lady of Modigliani.
Discovering his fanciful in Tenue correcte exigée, she played a Yiddish singer who fall in love for a gay clarinetist in Man Is a Woman, with Antoine de Caunes, while his companion. This mixture of romanticism and sheer lunacy could only tempt Raoul Ruiz, who heads the actress in Time Regained, but also in the eccentric Combat d'amour en songe and Ce jour-là. In 2006 she played Mathilde, an Orthodox Jewish woman faced with problems of his marriage to the side of Bruno Todeschini and Fanny Valette in Little Jerusalem. Demonstrating a remarkable eclecticism, she passes from a film of Akerman to a comedy with Kad Merad J'invente rien, a very personal variation around a novel by Christine Angot (Why (Not) Brazil ? by Laetitia Masson), a blockbuster based on a best-seller Le Concile de pierre (The Council of stone). In 2008, she is shown in two very contemporary chronic presented at the Berlin Festival, Il y a longtemps que je t'aime and La Fabrique des sentiments.