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George Clooney is an Academy Award winner who received three Oscar nominations in 2005 alone: Best Director, Best Original Screenplay (Good Night, and Good Luck.) and Best Supporting Actor (Syriana). It was the first time in Academy history that an individual received acting and directing nominations for two different films. That year, Clooney won the Oscar for Best Supporting Actor and a Golden Globe for his role in Syriana. He was also nominated for SAG, BAFTA and Critics' Choice awards for this performance and served as one of the film's executive producers.

In 2007, the Best Picture Oscar nominee Michael Clayton earned Clooney a Golden Globe and an Academy Award nomination for Best Actor.

In 2008, Clooney starred in Leatherheads, a romantic comedy he directed for Universal. It was the first film produced by Smokehouse, the production company Clooney formed with Grant Heslov.

Clooney's most recent film, the Coen brothers' Burn After Reading, was a surprise hit. It reunited him with the Coens for the third time, as they had previously collaborated on O Brother, Where Art Thou? (which earned Clooney a Golden Globe for Best Actor in a Motion Picture Musical or Comedy) and Intolerable Cruelty, co-starring Catherine Zeta Jones.

Clooney's upcoming projects include Up in the Air, directed by Jason Reitman, and the animated feature Fantastic Mr. Fox, in which he voices the title character.

Heslov and Clooney worked together at Section Eight, a company in which Clooney was partnered with Steven Soderbergh. Among the films produced by Section Eight were Ocean's 11, Ocean's 12, Ocean's 13, Michael Clayton, The Good German, Good Night, and Good Luck., Syriana, Confessions of a Dangerous Mind, The Jacket, Full Frontal and Welcome To Collinwood.

In Section Eight's television division, Clooney was an executive producer and directed five episodes of Unscripted, a reality-based show that debuted on HBO. He was executive producer and cameraman on K Street, also for HBO.

Clooney made his directorial debut in 2002 with Confessions of a Dangerous Mind, which won a Special Achievement in Film Award from the National Board of Review.

His second directorial project, Good Night, and Good Luck., brought him Oscar nominations for writing and directing as well as the Paul Selvin Award from the Writers Guild of America and the Freedom Award from the Broadcast Film Critics Association. The film also earned Clooney two Golden Globe nominations, two BAFTAs, a SAG Award, an Independent Spirit Award, two Critics' Choice Awards, a WGA Award and a DGA Award. For his overall cinematic achievements, he won the 2006 American Cinematheque Award and the Modern Master Award from the Santa Barbara Film Festival.

As an actor, Clooney received critical acclaim for the award-winning drama Three Kings and the Oscar-nominated Out of Sight. His other film credits include The Perfect Storm, Solaris, The Peacemaker, Batman & Robin, One Fine Day and From Dusk Till Dawn.

Clooney has starred in several television series but is best known to TV audiences for his five years on the hit drama ER. His portrayal of Dr. Douglas Ross earned him Golden Globe, Screen Actors Guild, People's Choice and Emmy nominations.

Clooney was executive producer and co-star of the live television broadcast of Fail Safe, an Emmy-winning telefilm developed through his Maysville Pictures. Fail Safe was nominated for a 2000 Golden Globe Award as Best Miniseries or Motion Picture Made for Television. The project was based on the early 1960s novel of the same name.

In 2006, Clooney and his father, Nick, went to Darfur to film the documentary Journey to Darfur. His work on behalf of Darfur relief led to the actor addressing the United Nations Security Council. He also narrated the Darfur documentary Sand and Sorrow.

In 2007, Clooney, along with Brad Pitt, Matt Damon, Don Cheadle and Jerry Weintraub, co-founded Not on Our Watch, an organization whose mission is to focus global attention and resources to halt and prevent mass atrocities in Darfur.

Among the many honors received as a result of Clooney's humanitarian efforts in Darfur was the 2007 Peace Summit Award, given at The 8th World Summit of Nobel Peace Prize Laureates at their annual meeting in Rome. Among those presiding over the ceremonies included Rome's mayor Walter Veltroni, Lech Walesa, Mikhail Gorbachev and the Dalai Lama. In 2008, Clooney was designated a U.N. Messenger of Peace. He was one of eight individuals chosen to advocate on behalf of the U.N. and its peacekeeping efforts.

The son of a television anchorman, Clooney has become a strong First Amendment advocate with a deep commitment to humanitarian causes.