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Eric Dane gained massive recognition early 2006 when he first appeared on Grey's Anatomy as Dr. Mark McSteamy Sloan. Grey's Anatomy was honored at the 2007 SAG Awards(TM) when its cast won the Screen Actors Guild Award for Best Performance by an Ensemble Cast, and at the 2007 Golden Globes, where the show won for Best Television Series-Drama.

Dane was raised in San Francisco, the older of two brothers whose father was an architect and interior designer and mother a homemaker. While excelling as an athlete in high school, he was bitten by the acting bug in a production of Arthur Miller's play All My Sons. After moving to Los Angeles in 1993, Dane made his TV debut on The Wonder Years, racking up guest roles on other series and recurring roles on Charmed, The American Embassy and, giving precedence to his current role, as a doctor on Gideon's Crossing. He has also appeared in several television films, including Serving in Silence and the remake of Helter Skelter. Most recently, he appeared in Wedding Wars opposite John Stamos.

On the big screen, Dane's first major role came in 1999 in the World War I film The Basket, and he was subsequently featured in the comedy Sol Goode. Other film credits include the tongue-in-cheek horror film Feast and Open Water: Adrift. Dane portrayed Jamie Madrox, aka Multiple Man, in the summer blockbuster hit X-Men: The Last Stand.