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Natasha Henstridge was born in Springdale, Newfoundland, Canada and raised in Fort McMurray, Alberta. She was barely a teen when she entered and earned the first runner-up prize in the Casablanca Modeling Agency's worldwide Look of the Year contest. At age 14, with the reluctant blessing of her parents, Henstridge left home to pursue a modeling career in New York and Paris. She landed her first cover on French Cosmopolitan when she was only 15, and has since graced the covers of many international fashion magazines. She has also appeared in commercials for such products as Lady Stetson, Oil of Olay and Old Spice.

Like many models-turned-actress before her, Henstridge grew tired of being just another pretty face and craved a more intellectually stimulating career. She left the runways of Paris for the lights of Hollywood and never looked back. At 21 she beat out hundreds of other doe-eyed hopefuls when she was cast in Species for MGM. She returned as an extraterrestrial in 1998 in Species II. More roles soon followed. She was cast in Maximum Risk with Jean-Claude Van Damme, Adrenaline: Fear the Rush, and appeared in an episode of Homeboys in Outer Space in 1996.

Then came the comedy hit The Whole Nine Yards, in which she played mob moll Cynthia Tudeski, the estranged wife of a hit man (Bruce Willis) who manages to charm her way out of dangerous situations. Matthew Perry plays her love interest in the film, which garnered Henstridge critical praise.

In 2000 Henstridge appeared in the Ben Affleck romantic film, Bounce. In 2001 she accepted the role of Cassie in the television series She Spies, which lasted two seasons and is currently finding success in syndication. She also starred in ABC's Commander & Chief, opposite Geena Davis, in 2005 and is currently starring in the ABC legal drama, Eli Stone.

Henstridge is happily settled in the Hollywood Hills of Los Angeles with her sons, Tristan and Asher.